Endocrine Abstracts

Objectives: Growing interest has been focused on the role of atrial natriuretic peptide (ANP) in the protection of cardiac and vascular integrity. Moreover, ANP enhances lipolysis and fat-oxidation. However, the impact of exercise on ANP in obesity is not yet investigated. The aim of this study was to evaluate the modulation of exercise-induced changes in ANP in obesity.Methods: We studied the hormonal and metabolic responses to 30 min exercise on cyclo-...

Objectives: Insulin interacts with the GH – insulin-like growth factor (IGF) system by a reciprocal regulation of IGF-binding proteins (IGFBPs) and GH, which in turn interact to regulate insulin sensitivity (IS). We previously showed that IGFBP-2 is involved in the insulin-induced reduction in IGF1 bioactivity. We here address the modulation of IGF1 bioactivity during acute lipid-induced insulin resistance.Methods: 18 healthy men (30.8±2.6 year...

Objectives: Atrial natriuretic peptide (ANP) is a cardiac hormone that is known to play an essential role in regulation of blood pressure and vascular endothelial function. However, the metabolic regulation of ANP is not fully understood. In patients with the metabolic syndrome, hyperglucagonemia is a common feature, besides hypertension and hyperinsulinemia. Our aim was to evaluate the impact of glucagon on proANP and the possible mechanisms underlying this effect.<p clas...

Objectives: Brain Derived Neurotrophic Factor (BDNF) plays a fundamental role in regulation of metabolism and energy homeostasis. Low BDNF levels have been identified as possible biological causes for development of obesity and BDNF administration has been shown to induce weight loss and to improve insulin sensitivity in diabetic animal models. Acute exercise is known to induce a transient increase of peripheral BDNF but no information is yet available regarding the exercise-i...

Objectives: GH measurements during OGTT have profound effects on therapy and follow-up management of acromegaly. To minimize the discordance between immunoassays, it is recommended to calibrate them using 22 kDa-GH-preparation instead of the use of pituitary-derived calibrants. The aim of our study was to evaluate the between-method discrepancies in GH determinations by assays using different calibrants considering further confounders like age, gender, and BMI.<p class="ab...